Christopher G Proud Selected Research

Elongation Factor 2 Kinase

1/2021	Elongation factor eEF2 kinase and autophagy jointly promote survival of cancer cells.
1/2020	Eukaryotic elongation factor 2 kinase promotes angiogenesis in hepatocellular carcinoma via PI3K/Akt and STAT3.
1/2018	Eukaryotic elongation factor 2 kinase upregulates the expression of proteins implicated in cell migration and cancer cell metastasis.
11/2016	A high-throughput screening assay for eukaryotic elongation factor 2 kinase inhibitors.
3/2016	Eukaryotic elongation factor 2 kinase as a drug target in cancer, and in cardiovascular and neurodegenerative diseases.
5/2015	Molecular Mechanism for the Control of Eukaryotic Elongation Factor 2 Kinase by pH: Role in Cancer Cell Survival.
5/2015	Elongation Factor 2 Kinase Is Regulated by Proline Hydroxylation and Protects Cells during Hypoxia.

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Christopher G Proud Research Topics

Disease

37	Neoplasms (Cancer) 01/2022 - 01/2004
14	Starvation 01/2019 - 11/2002
9	Leukoencephalopathies 12/2015 - 11/2003
8	Cardiomegaly (Heart Hypertrophy) 10/2016 - 11/2002
5	Tuberous Sclerosis (Bourneville's Disease) 04/2021 - 05/2005
5	Neoplasm Metastasis (Metastasis) 01/2019 - 04/2015
4	Obesity 05/2021 - 12/2020
4	Carcinogenesis 01/2021 - 08/2013
3	Inflammation (Inflammations) 01/2022 - 01/2016
3	Insulin Resistance 05/2021 - 01/2018
3	Lung Neoplasms (Lung Cancer) 01/2021 - 01/2020
3	Neurodegenerative Diseases (Neurodegenerative Disease) 03/2016 - 01/2004
3	Nervous System Diseases (Neurological Disorders) 12/2015 - 03/2012
3	Hypoxia (Hypoxemia) 05/2015 - 04/2009
2	Inborn Genetic Diseases (Disease, Hereditary) 01/2022 - 04/2011
2	Hyperglycemia 01/2021 - 08/2008
2	Dementia (Dementias) 01/2021 - 10/2017
2	Colorectal Neoplasms (Colorectal Cancer) 01/2021 - 01/2019
2	Hepatocellular Carcinoma (Hepatoma) 01/2020 - 06/2007
2	Breast Neoplasms (Breast Cancer) 07/2017 - 06/2012
2	Acidosis 05/2015 - 04/2015
2	Hypertrophy 06/2013 - 07/2004
2	Ischemia 01/2007 - 10/2002
2	Brain Ischemia (Cerebral Ischemia) 01/2007 - 10/2002
2	Brain Diseases (Brain Disorder) 04/2006 - 11/2003
1	Liver Failure 01/2022
1	Cholestasis 01/2022
1	Intrahepatic Cholestasis 01/2022
1	Gallbladder Diseases (Gall Bladder Disease) 01/2022
1	Atherosclerosis 01/2022
1	Atherosclerotic Plaque (Atheroma) 01/2022
1	Extrahepatic Cholestasis 01/2022
1	Leukemia 07/2021
1	Thinness 02/2021
1	Weight Gain 02/2021
1	Overnutrition 02/2021
1	Neuroinflammatory Diseases 01/2021
1	Autoimmune Diseases (Autoimmune Disease) 10/2020
1	Uterine Cervical Neoplasms (Cancer of the Cervix) 01/2020
1	Liver Neoplasms (Liver Cancer) 01/2020
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 06/2019
1	Metabolic Diseases (Metabolic Disease) 01/2019

Drug/Important Bio-Agent (IBA)

41	Proteins (Proteins, Gene)FDA Link 01/2021 - 10/2002
20	Mechanistic Target of Rapamycin Complex 1IBA 05/2021 - 06/2007
12	Eukaryotic Initiation Factor-2B (Eukaryotic Initiation Factor 2B)IBA 01/2022 - 10/2002
10	Eukaryotic Initiation Factor-4EIBA 07/2021 - 12/2002
9	Phosphotransferases (Kinase)IBA 01/2022 - 10/2002
9	Amino Acids FDA Link 01/2019 - 05/2005
8	TOR Serine-Threonine KinasesIBA 05/2014 - 04/2005
7	Elongation Factor 2 KinaseIBA 01/2021 - 05/2015
6	Messenger RNA (mRNA)IBA 01/2022 - 01/2004
6	Insulin (Novolin)FDA Link 05/2021 - 05/2005
5	Phenylephrine (Neo-Synephrine)FDA LinkGeneric 10/2016 - 11/2002
5	Peptide Initiation Factors (Initiation Factor)IBA 08/2015 - 10/2002
5	Sirolimus (Rapamycin)FDA Link 08/2015 - 06/2007
3	Protein Kinases (Protein Kinase)IBA 07/2021 - 11/2020
3	Glucose (Dextrose)FDA LinkGeneric 05/2021 - 01/2018
3	MTOR InhibitorsIBA 01/2021 - 08/2013
3	EnzymesIBA 07/2018 - 04/2009
2	CholesterolIBA 01/2022 - 01/2017
2	Glutamine (L-Glutamine)FDA Link 01/2022 - 01/2019
2	LipidsIBA 02/2021 - 12/2020
2	Mitogen-Activated Protein KinasesIBA 12/2020 - 01/2019
2	Small Interfering RNA (siRNA)IBA 01/2020 - 01/2019
2	RNA (Ribonucleic Acid)IBA 10/2016 - 06/2012
2	Leucine (L-Leucine)FDA Link 01/2016 - 09/2014
2	70-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)IBA 08/2003 - 10/2002
2	Endothelin-1 (Endothelin 1)IBA 11/2002 - 11/2002
1	Fenofibrate (CiL)FDA LinkGeneric 01/2022
1	Bile Acids and Salts (Bile Acids)IBA 01/2022
1	Interleukin-6 (Interleukin 6)IBA 01/2022
1	Glutathione Disulfide (GSSG)FDA LinkGeneric 01/2022
1	Glutathione (Reduced Glutathione)IBA 01/2022
1	Ribosomal RNAIBA 01/2022
1	GW 6471IBA 01/2022
1	daisaikotoIBA 01/2022
1	tomivosertibIBA 07/2021
1	Peptide Elongation Factors (Elongation Factor)IBA 01/2021
1	DNA (Deoxyribonucleic Acid)IBA 12/2020
1	Immune Checkpoint ProteinsIBA 11/2020
1	Immune Checkpoint InhibitorsIBA 11/2020
1	B7-H1 AntigenIBA 11/2020
1	Cyclosporine (Ciclosporin)FDA LinkGeneric 10/2020
1	Tacrolimus (Prograf)FDA LinkGeneric 10/2020
1	Immunosuppressive Agents (Immunosuppressants)IBA 10/2020
1	Gefitinib (Iressa)FDA Link 01/2020
1	Eukaryotic Initiation Factor-2 (EIF 2)IBA 01/2020
1	Growth Factor ReceptorsIBA 01/2020
1	Peptide Elongation Factor 2 (EF-2)IBA 01/2020
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2020
1	Prokaryotic Initiation Factor-2IBA 01/2020
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2020
1	Lysosomal-Associated Membrane Protein 3IBA 01/2020
1	Adenine FDA LinkGeneric 06/2019
1	aniline (aniline hydrobromide)IBA 01/2019

Therapy/Procedure

11	Therapeutics 04/2021 - 08/2013
2	Caloric Restriction 05/2021 - 05/2013
2	Immunotherapy 01/2021 - 11/2020
1	Ligation 01/2022
1	Organ Transplantation 10/2020